Can SCE & SCCM Co-exist in the Same AD Domain?

We're a small company, but finding significant deficiencies in SCE regarding Software Inventory (only what Add/Remove Programs shows you, not the version of the Update) and also Software Distribution (no custom command, no forced reboots, no dependencies, etc.)

Having exeprience (a long time ago) with SMS 2.0, I would like to *test* SCCM now, but do not want to negatively impact my users who are using SCE.

Can I install SCCM without distrupting the SCE clients?